15th European Conference on Artificial Intelligence
  July 21-26 2002     Lyon     France  
   

ECAI-2002 Conference Paper

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Dealing with Discontinuities in the Qualitative Simulation of Genetic Regulatory Networks

Hidde de Jong, Jean-Luc Gouzé, Céline Hernandez, Michel Page, Tewfik Sari, Hans Geiselmann

Methods developed for the qualitative simulation of dynamical systems have turned out to be powerful tools for studying genetic regulatory networks. We present a generalization of a simulation method based on piecewise-linear differential equation models that is able to deal with discontinuities. The method is sound and has been implemented in a computer tool called GNA.

Keywords: Qualitative Reasoning, Bioinformatics, model-based reasoning

Citation: Hidde de Jong, Jean-Luc Gouzé, Céline Hernandez, Michel Page, Tewfik Sari, Hans Geiselmann: Dealing with Discontinuities in the Qualitative Simulation of Genetic Regulatory Networks. In F. van Harmelen (ed.): ECAI2002, Proceedings of the 15th European Conference on Artificial Intelligence, IOS Press, Amsterdam, 2002, pp.412-416.


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ECAI-2002 is organised by the European Coordinating Committee for Artificial Intelligence (ECCAI) and hosted by the Université Claude Bernard and INSA, Lyon, on behalf of Association Française pour l'Intelligence Artificielle.